Poxet

Poxet represents a significant advancement in the pharmacological management of premature ejaculation (PE), offering men a reliable and well-tolerated treatment option. This product card provides a comprehensive, expert-level overview of Poxet, detailing its mechanism of action, appropriate usage, and essential safety information. It is formulated with dapoxetine hydrochloride, a selective serotonin reuptake inhibitor (SSRI) specifically developed and approved for this indication, distinguishing it from antidepressants used off-label.

Features

• Active Ingredient: Dapoxetine Hydrochloride.
• Available Strengths: 30 mg and 60 mg tablets.
• Pharmacological Class: Selective Serotonin Reuptake Inhibitor (SSRI).
• Onset of Action: Rapid absorption, designed for use approximately 1-3 hours before anticipated sexual activity.
• Duration: Short half-life, minimizing long-term systemic exposure.
• Administration: Oral tablet, with or without food.

Benefits

• Significantly Increases Intravaginal Ejaculatory Latency Time (IELT): Clinical trials demonstrate a substantial, statistically significant increase in time to ejaculation.
• Improves Perceived Control Over Ejaculation: Users report a greater sense of command during sexual activity, reducing performance-related anxiety.
• Enhances Sexual Satisfaction for Both Partners: Effective management of PE leads to improved sexual experience and relationship satisfaction.
• On-Demand Dosing Regimen: Provides flexibility and avoids the need for daily medication, aligning treatment with sexual activity.
• Well-Established Safety Profile: Extensive clinical data supports its tolerability when used as directed under medical supervision.

Common use

Poxet is indicated for the treatment of premature ejaculation (PE) in adult men aged 18 to 64 years. PE is defined as a persistent or recurrent pattern of ejaculation occurring within approximately one minute of vaginal penetration (lifelong PE) or a clinically significant reduction in latency time, often to three minutes or less (acquired PE), and which causes the individual distress and interpersonal difficulty. It is intended for men who exhibit these diagnostic criteria and seek a pharmacological intervention. It is not intended for use by the general population to enhance sexual performance.

Dosage and direction

The recommended starting dose is 30 mg, taken orally with a full glass of water approximately 1 to 3 hours before anticipated sexual activity. The dosing may be increased to a maximum of 60 mg based on efficacy and tolerability, as determined by a prescribing physician. It is not recommended to take more than one dose within a 24-hour period. The tablet can be taken with or without food; however, consumption with a large or high-fat meal may delay absorption and slightly reduce the maximum concentration of the drug in the bloodstream. The efficacy of Poxet is established only in connection with sexual stimulation; it does not spontaneously cause erection or increase libido.

Precautions

Prior to initiating treatment with Poxet, a medical evaluation should be conducted to confirm the diagnosis of PE and rule out other underlying medical or psychological conditions. Use with caution in patients with a history of mood disorders. Patients should be monitored for the emergence of serotonin syndrome, a potentially life-threatening condition, especially when co-administered with other serotonergic drugs. Due to risk of syncope (fainting) and pre-syncope (dizziness), patients should be advised to avoid situations where injury could occur should they experience these effects. Caution is advised in patients with mild to moderate renal or hepatic impairment; it is not recommended for those with severe impairment. This medication may cause dizziness and somnolence; patients should not drive, operate machinery, or engage in potentially hazardous activities until they know how the drug affects them.

Contraindications

Poxet is contraindicated in patients with:

• Known hypersensitivity to dapoxetine or any of the tablet’s excipients.
• Significant pathological cardiac conditions such as heart failure (NYHA Class II-IV), conduction abnormalities (e.g., sick sinus syndrome, sinoatrial or AV block), significant ischemic heart disease, or significant valvular disease.
• History of mania or severe depression.
• Concomitant administration with monoamine oxidase inhibitors (MAOIs), thioridazine, or other potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir, saquinavir, telithromycin, nefazodone, nelfinavir, atazanavir). A significant washout period (at least 14 days) is required after discontinuing an MAOI before starting Poxet, and vice versa.

Possible side effect

As with all pharmaceuticals, Poxet can cause side effects, although not everybody gets them. Most are mild to moderate and often diminish with continued use.

• Very Common (≥1/10): Headache, dizziness, nausea.
• Common (≥1/100 to <1/10): Diarrhea, insomnia, somnolence (sleepiness), fatigue, anxiety, vomiting, abdominal pain, flushing, increased sweating, tremors, blurred vision, tinnitus, hypertension.
• Uncommon (≥1/1,000 to <1/100): Syncope (fainting), attention disturbances, disorientation, euphoric mood, tension, decreased libido, dyspnea, heart palpitations, tachycardia, hot flush, erectile dysfunction, malaise, irritability.
• Rare: Priapism (prolonged and painful erection). This is a medical emergency and requires immediate treatment.

Drug interaction

Dapoxetine is primarily metabolized by multiple CYP enzymes (CYP2D6, CYP3A4, CYP2C19, CYP2C9, CYP2B6, CYP1A2, CYP2C8). Concomitant use with drugs that inhibit these enzymes can significantly increase dapoxetine exposure.

• Absolute Contraindication: MAOIs, thioridazine, potent CYP3A4 inhibitors (see Contraindications).
• Use with Caution / Not Recommended: Other SSRIs, SNRIs, tricyclic antidepressants, antipsychotics, opioids (tramadol, fentanyl), triptans, tryptophan, St. John’s Wort, and other serotonergic drugs (increased risk of serotonin syndrome). Moderate CYP3A4 inhibitors (e.g., erythromycin, clarithromycin, fluconazole, diltiazem). CYP2D6 inhibitors (e.g., fluoxetine, paroxetine).
• Alcohol: Concurrent use with alcohol may increase the risk of adverse events such as dizziness, drowsiness, and slowed judgment. It is recommended to avoid alcohol while taking Poxet.

Missed dose

Poxet is taken on an as-needed basis, not on a scheduled daily regimen. Therefore, the concept of a “missed dose” does not apply. Do not take a double dose to make up for a missed opportunity. Simply take the next single dose (30mg or 60mg) 1-3 hours before your next anticipated sexual activity, ensuring at least 24 hours have passed since your last dose.

Overdose

In case of overdose, expected symptoms would be an extension of the known adverse effects, particularly serotonin syndrome (agitation, confusion, diaphoresis, hallucinations, hyperreflexia, myoclonus, shivering, tachycardia, hypertension, hyperthermia), syncope, dizziness, nausea, vomiting, and somnolence. There is no specific antidote for dapoxetine overdose. Treatment should consist of general supportive measures, including monitoring of vital signs and ECG. Gastric lavage and administration of activated charcoal may be considered if presented early. Ensure an adequate airway, oxygenation, and ventilation.

Storage

Store below 30°C (86°F). Keep the blister strips in the outer carton to protect from light and moisture. Keep out of the sight and reach of children. Do not use after the expiration date printed on the packaging. Do not dispose of medication via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here. The efficacy and safety of this product have not been evaluated by all international regulatory bodies; it is approved for use in specific markets. Always use prescription medications exactly as prescribed by your healthcare provider.

Reviews

• Dr. A. Sharma, Urologist: “In my practice, Poxet (dapoxetine) has become a first-line pharmacological option for suitable patients with lifelong PE. The on-demand profile is a significant advantage over daily SSRIs, and the clinical data on IELT improvement is robust. Patient satisfaction, particularly regarding regained control, is consistently high. My primary advice is to manage patient expectations—it is a tool for management, not an instant cure, and must be part of a broader discussion about sexual health.”
• Clinical Study Participant, Phase III Trial: “I was part of a blinded study a few years ago. The difference on the active drug versus the placebo was night and day for me. It gave me the few extra minutes I desperately needed, which drastically reduced my anxiety. The side effects were there initially (some dizziness and mild nausea) but faded after the first few uses.”
• Mark T., 42: “After struggling with PE for over a decade and trying behavioral techniques with limited success, my doctor prescribed Poxet. It has genuinely changed my sex life and my confidence. The key for me was starting on the lower dose to assess tolerance. The effect is reliable, and I appreciate that I only take it when I need it.”