Levitra Extra Dosage: Advanced Erectile Dysfunction Therapy
Levitra
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Synonyms | |||
Similar products
Levitra Extra Dosage (vardenafil hydrochloride) represents a potent pharmacological option for men experiencing moderate to severe erectile dysfunction (ED). This formulation delivers a higher concentration of the active ingredient, vardenafil, a selective phosphodiesterase type 5 (PDE5) inhibitor, designed to provide a robust and reliable therapeutic response. It functions by enhancing blood flow to the penile tissue upon sexual stimulation, facilitating the achievement and maintenance of an erection sufficient for satisfactory sexual activity. This product is intended for use under medical supervision following a comprehensive clinical evaluation to determine patient suitability and rule out underlying cardiovascular contraindications.
Features
- Active Pharmaceutical Ingredient: Vardenafil hydrochloride.
- Dosage Strength: Available in an extra dosage formulation, typically 20mg per tablet, though specific strengths are determined by a healthcare provider.
- Pharmacological Class: Selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).
- Mechanism of Action: Potentiates the effect of nitric oxide (NO) by inhibiting PDE5, which is responsible for the degradation of cGMP in the corpus cavernosum.
- Onset of Action: Clinical effects are typically observed within 25-60 minutes post-administration.
- Duration of Effect: The therapeutic window can extend for up to 5 hours, though individual response may vary.
- Administration: Oral tablet, to be taken with or without food. High-fat meals may delay the rate of absorption.
- Prescription Status: Available by prescription only following a medical consultation.
Benefits
- Enhanced Efficacy in Challenging Cases: The higher dosage strength is specifically formulated for individuals who have demonstrated a suboptimal response to standard-dose PDE5 inhibitor therapy, offering a more potent therapeutic option.
- Improved Erection Hardness: Facilitates the attainment of a significantly firmer erection (often quantified on scales like the Erection Hardness Score) compared to placebo or lower doses, which is crucial for successful intercourse.
- Increased Spontaneity and Confidence: The extended duration of action provides a wider window of opportunity for sexual activity, reducing performance anxiety and planning stress associated with ED.
- High Reliability: Demonstrated consistent results in clinical trials across various etiologies of ED, including cases related to diabetes mellitus and post-radical prostatectomy.
- Rapid Onset: Allows for a relatively quick response time, enabling a more natural and less scheduled intimate experience.
Common use
Levitra Extra Dosage is primarily indicated for the treatment of erectile dysfunction (ED) in adult males. ED is defined as the consistent or recurrent inability to achieve and/or maintain a penile erection sufficient for satisfactory sexual performance. This medication is not indicated for use by women, children, or adolescents. It is crucial to understand that sexual stimulation is required for Levitra to be effective; it is not an aphrodisiac and will not trigger an erection in the absence of sexual arousal.
Dosage and direction
The dosing of Levitra Extra Dosage must be individualized based on efficacy and tolerability under the direct guidance of a prescribing physician.
- Standard Recommended Dose: The typical recommended dose is one 20mg tablet, taken orally, approximately 25 to 60 minutes before anticipated sexual activity.
- Dosing Frequency: The maximum recommended dosing frequency is once per 24-hour period.
- Administration: The tablet can be taken with or without food. However, consumption with a high-fat meal may delay the time to maximum plasma concentration (Tmax), potentially slowing the onset of effect.
- Dosage Adjustment: For patients with specific health considerations, such as moderate hepatic impairment (Child-Pugh B), a lower starting dose of 5mg or 10mg is recommended. Dose adjustment may also be necessary for individuals taking certain concomitant medications (see Drug Interactions).
- Elderly Patients: Dosage adjustment based on age is not ordinarily necessary, but greater sensitivity to medications in some older individuals necessitates caution.
Precautions
- Cardiovascular Status: Patients with pre-existing cardiovascular disease (e.g., unstable angina, heart failure, arrhythmias, recent myocardial infarction) should be evaluated for cardiovascular risk prior to initiating any sexual activity, as sexual activity itself carries a potential cardiac risk. Levitra is contraindicated in patients for whom sexual activity is inadvisable.
- Priapism: Prolonged erection lasting more than 4 hours and priapism (a painful erection lasting more than 6 hours) have been reported infrequently. This condition requires immediate medical attention to avoid long-term penile tissue damage and permanent impotence.
- Effects on the Eye: Non-arteritic anterior ischemic optic neuropathy (NAION), a cause of decreased vision or permanent vision loss, has been reported rarely post-marketing in connection with PDE5 inhibitor use. Patients who have experienced NAION in one eye are at increased risk of NAION in the other eye.
- Sudden Hearing Loss: Sudden decrease or loss of hearing has been reported, sometimes accompanied by tinnitus and dizziness.
- Alpha-blockers and Antihypertensives: Concomitant use can potentiate the blood-pressure-lowering effects (see Drug Interactions).
- Renal or Hepatic Impairment: Dosage adjustment is recommended for patients with significant hepatic impairment. For severe renal impairment (creatinine clearance <30 mL/min), a starting dose of 5mg is recommended.
Contraindications
Levitra Extra Dosage is strictly contraindicated in the following patient populations:
- Patients using any form of organic nitrates (e.g., nitroglycerin, isosorbide mononitrate or dinitrate) or nitric oxide donors (e.g., amyl nitrite “poppers”) in any dosage form (regular or intermittent), due to the risk of a profound and potentially fatal drop in blood pressure.
- Patients with a known hypersensitivity to vardenafil or any of the inactive ingredients in the formulation.
- Patients for whom sexual activity is not recommended due to underlying cardiovascular status.
Possible side effect
Like all medications, Levitra can cause side effects, although not everybody gets them. Common side effects are typically mild to moderate and transient.
- Very Common (≥1/10): Headache.
- Common (≥1/100 to <1/10): Flushing, nasal congestion, dyspepsia (indigestion), dizziness.
- Uncommon (≥1/1,000 to <1/100): Palpitations, tachycardia, nausea, increased creatine kinase, blurred vision, changes in color vision (cyanopsia).
- Rare (≥1/10,000 to <1/1,000): Hypotension, syncope (fainting), priapism, NAION, sudden hearing loss.
- Frequency Not Known: Seizure, transient global amnesia.
Drug interaction
Concomitant use of certain drugs can lead to significant interactions.
- Nitrates: Absolute Contraindication. Concomitant use can cause severe hypotension, syncope, stroke, or myocardial infarction.
- Alpha-blockers (e.g., doxazosin, tamsulosin): Use with caution. Both classes lower blood pressure. Concomitant use can lead to symptomatic hypotension (dizziness, lightheadedness, fainting). A time interval between doses should be observed, and the alpha-blocker should be stable before initiating vardenafil at the lowest dose.
- Other Antihypertensives: Additive blood-pressure-lowering effects are possible.
- Potent CYP3A4 Inhibitors: Drugs like ketoconazole, itraconazole, indinavir, ritonavir, and clarithromycin significantly increase vardenafil plasma concentrations. A maximum vardenafil dose of 5mg in a 24-hour period (or 2.5mg with ritonavir) is recommended.
- Moderate CYP3A4 Inhibitors: Drugs like erythromycin and aprepitant require caution, and a maximum dose of 5mg vardenafil in 24 hours should not be exceeded.
Missed dose
Levitra Extra Dosage is not intended for scheduled daily use; it is taken on an as-needed basis prior to sexual activity. Therefore, the concept of a “missed dose” does not apply. Do not take an extra tablet to make up for a missed opportunity.
Overdose
In cases of suspected overdose, standard supportive measures should be employed. Given the vasodilatory effects of vardenafil, the primary expected manifestation of overdose would be severe hypotension. Cardiovascular status should be monitored and appropriate management for hypotension instituted (e.g., placing the patient in the supine position with the legs elevated, fluid administration). Dialysis is not expected to accelerate clearance as vardenafil is highly protein-bound.
Storage
- Store at room temperature between 20°C to 25°C (68°F to 77°F). Excursions are permitted between 15°C and 30°C (59°F and 86°F).
- Keep in the original blister package to protect from moisture and light.
- Keep this medication out of the sight and reach of children and pets.
- Do not use after the expiration date printed on the packaging.
Disclaimer
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here. The information provided may not cover all possible uses, directions, precautions, drug interactions, or adverse effects.
Reviews
- Clinical Efficacy Data: In pivotal phase III clinical trials, patients receiving vardenafil 20mg reported significantly improved erectile function compared to placebo. For example, per the International Index of Erectile Function (IIEF) Erectile Function domain score, improvements were statistically significant (p<0.0001). Success rates for penetration (SEP2) and successful intercourse (SEP3) were also markedly higher.
- Patient Testimonials (Aggregated Theme): Many users who did not achieve desired results with other therapies report a pronounced improvement in erection quality and reliability with the extra dosage formulation. Common feedback highlights the rapid onset and the confidence derived from its efficacy. Some users note the side effects (like headache or flushing) are more pronounced but often manageable and considered a worthwhile trade-off for the therapeutic benefit.
- Physician Endorsement: Urologists and other prescribing clinicians often reserve this higher dosage for patients with more severe ED or those who are non-responders to first-line PDE5 inhibitor therapy. It is recognized as a valuable tool within the ED treatment armamentarium for appropriate, carefully selected patients.